Noted for having incredible power and a slow reload time, this weapon draws immediate comparisons to the Desert Eagle. The low magazine size of six bullets combined with a slow reload require precision shots, however with skill the weapon is capable of dispatching nearly any foe with one shot.
It is not equipped with a tactical flashlight. In the original game, in team-based weapons, this weapon is only available to Suspects. Starting in The Stetchkov Syndicate, it is only available to SWAT officers.
Be aware the game says the gun fires in double-action this is not true, the Colt python fires in single-action only.
|SWAT 4 Weapons|
|SWAT 4||Assault Rifles||Colt M4A1 Carbine - AKM Assault Rifle - G36C Assault Rifle|
|Submachine Guns||MP5A4 SMG (Suppressed MP5A4 SMG) - UMP SMG - Suppressed Uzi|
|Shotguns||Benelli Nova - Benelli M4Super90|
|Pistols||Colt Python - Colt M1911 (VIP Colt M1911) - Glock 18|
|Less Lethal||Less Lethal Nova - Pepperball Gun - Taser Stun Gun|
|TSS||Submachine Guns||FN P90 - TEC-DC9|
|Less Lethal||HK69 Grenade Launcher - Cobra Stun Gun|
|Other||M249 SAW Light Machine Gun - Colt Accurized Rifle|
|SEF||Assault Rifles||Colt M16A2 Assault Rifle (Suppressed Colt M16A2 Assault Rifle) - SG552 Commando (Suppressed SG552 Commando) - HK33 (Scoped HK33) - Suppressed M4A1 Carbine - Suppressed G36C Assault Rifle|
|Submachine Guns||MP5SD6 SMG - Suppressed UMP SMG - MP5KA4 SMG (Suppressed MP5KA4 SMG)|
|Shotguns||Remington M870 (Remington M870 Breaching)|
|Pistols||Browning Hi-Power (Suppressed Browning Hi-Power) - P226 (Suppressed P226)|
|Less Lethal||ARWEN 37 - Less Lethal M870|